Stereoselective synthesis of (-)-acanthoic acid.
نویسندگان
چکیده
[reaction: see text] The first stereoselective synthesis of (-)-acanthoic acid (1) has been designed and accomplished. Our synthetic plan departs from (-) Wieland-Miesher ketone (7) and calls upon a Diels-Alder cycloaddition reaction for the construction of the C ring of 1. The described synthesis confirms the proposed stereochemistry of 1 and represents an efficient entry into an unexplored class of biologically active diterpenes.
منابع مشابه
Effects of acanthoic acid on TNF-alpha gene expression and haptoglobin synthesis.
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عنوان ژورنال:
- Organic letters
دوره 2 14 شماره
صفحات -
تاریخ انتشار 2000